Professor Zaius' story was told in the Planet of the Apes PC game by UbiSoft. His first appearance in the game can be viewed here. Upon escaping from his cell in the Ape laboratories, Ulysses crawled through the air ducts to where he saw Zaius talking to Doctor Zira. He was against the special treatment favoured by Zira towards Ulysses, who she saw as a very unusual human. Reminding her of his authority, Zaius told her that Ulysses will be transferred to the mandrill militia. Ulysses encountered Zaius again when he entered the Ape High Council chamber, where Zaius was chairing the Council. On reading the evidence Ulysses had gathered about Ursus' secret plot, Zaius ordered the arrest of Ursus and, despite the protests of the other Council members, offered Ulysses the chance to go free if he never returned to the Ape City. Ulysses agreed and Zaius then explained that his apparent gratitude was in truth a calculated plan to portray Ulysses as a selfish coward rather than the heroic leader of the human resistance he had become. Just as Ulysses and Nova made their escape however, Mathias was already assembling a huge human army to attack Ape City.
- The character of Zaius is based on Dr. Zaius from Planet of the Apes and Beneath the Planet of the Apes.