While he slept, Wolfie and the other apes were exposed to ALZ-113 by Caesar. Wolfie gained new intelligence because of this and would join the other apes as Caesar prepared to lead them to freedom.
After Caesar rebelled, Wolfie would be liberated from his cell and escape the shelter with his comrades. He accompanied Caesar's group as they moved to free all apes in the city. Wolfie later smashed a camera during the mass-breakout from the Gen-Sys Laboratories.
He was present during the assault on the Golden Gate Bridge and followed Koba in scaling the bridge's support struts. He was shot in the back by a police helicopter gunner, losing his grip and frantically trying to hang on before plummeting to his death in the waters below.
Seeing him die enraged Maurice, who watched from below the bridge.
- The name of this chimpanzee character was revealed by director Rupert Wyatt in the commentary track of the Rise of the Planet of the Apes blu-ray disc. He was named after Wolfie Smith, the urban guerilla hero of British comedy series Citizen Smith, who was in turn named after Irish revolutionary Theobald Wolfe Tone (who used the pseudonym "Citizen Smith").