Burke was among a number of chimpanzees held at the Gen-Sys Laboratories for experimental research into the "ALZ-112" drug, when wild African chimp Bright Eyes was first brought to the facility. Other chimps held there included Lorelei, Chambers and Verdon. A military-sanctioned variant of the drug was administered to Burke and Verdon, the latter of whom was shot attempting to escape. Burke later retreated into a fantasy world as the experimental drug drove him insane. He was taken away from the lab as he was of no further use.